OBJECTIVE: To concurrently validate three health-related quality of life (HRQOL) measures in patients with schizophrenia in Singapore. METHODS: A consecutive sample of outpatients with schizophrenia seen at a psychiatric hospital completed English or Chinese versions of the Schizophrenia Quality of Life Scale (SQLS) and the Short Form 36 Health Survey (SF-36) twice during 2 different visits. At baseline, patients also completed the Health Utilities Index Mark 3 (HUI3) and were assessed for psychotic symptoms using a standard checklist. Construct validity was assessed using factor analysis, item-scale correlation matrix and by examining hypothesized correlations; reliability using Cronbach's alpha and intraclass correlation coefficients (ICC); and responsiveness using Cohen's effect size measure (d) and paired t-tests. RESULTS: Baseline and follow-up surveys were completed by 202 (English-speaking=140) and 117 subjects respectively (median interval: 25 days). Item-scale correlation matrix and factor analysis results supported construct validity of the SQLS. Correlations between the three measures and psychotic symptoms were generally as hypothesized (Spearman's rho: 0.20-0.61, p<0.01 for all). Cronbach's alpha ranged from 0.59 to 0.93 for SQLS and 0.57 to 0.82 for SF-36 scales. ICCs ranged from 0.46 to 0.82 for SQLS and 0.32 to 0.59 for SF-36 scales. SQLS psychosocial and SF-36 role-physical, general health, vitality, social functioning and role-emotional scale scores improved with improvements in self-reported global health; SQLS symptoms/side effects and SF-36 social functioning scale scores worsened with worsening self-reported global health (effect size: 0.3-0.4, paired t-tests: p<0.05 for all). English and Chinese versions of the SQLS showed similar degrees of construct validity, reliability and responsiveness. CONCLUSIONS: The SQLS, SF-36 and HUI3 appear to be valid, reliable and responsive (for the SQLS & SF-36) HRQOL measures in outpatients with schizophrenia in Singapore. Singaporean English and Chinese versions of SQLS appear to be psychometrically equivalent.