OBJECTIVES: The IQOD Programme aims at standardising the administration of PRO questionnaires. The work is based on the analysis of multinational item responses to questionnaires additionally to clinical and socio-demographic variables. It involves the Women's Health Questionnaire (WHQ), the Psychological General Well-Being Index (PGWBI), and the Minnesota Living with Heart Failure (MLHF) to better know their use: administration, psychometric properties, scoring, reference values, and subgroups scores comparisons. METHODS: Multinational studies data have been collected, anonymised, harmonised and merged into three single databases. Statistical analysis, validating the psychometric properties, included: Principal Components Analysis, Multitrait Analysis, Item Response Theory methods, Reliability coefficient. For PGWBI database analysis also included Confirmatory Factorial Analysis and Structural Equation Modelling. Moreover, to establish score's comparison between subgroups parametric and non-parametric methods were used. RESULTS: The current results concern the WHQ (n=9 525 women, 85 variables, 11 languages) and the PGWBI (n=8 536 patients with 5 main pathologies, 150 variables, 16 languages) databases evaluation. This allowed validating the psychometric properties and cross cultural equivalence, and establishing reference values per country, subgroup, disease severity, with socio-demographic or clinical concerns. - The WHQ is sensitive to symptom severity: women with severe hot flushes, palpitation, irritation or insomnia had lower scores than their controls. Its scoring has been reviewed with the author. The validity of the ten-country WHQ-database has shortened the WHQ to a 23-item version. The PGWBI database analysis shows that all of the strong patterns of item means within subscale across languages are consistent with what would be expected, in the presence of language equivalence. CONCLUSION: The IQOD Programme provides a comprehensive, standardised, and evidence-based interpretation of WHQ and PGWBI with instruction manuals and related databases. The latter are valuable tools for extending the knowledge of these questionnaires.