OBJECTIVES: Individuals with inherited mutations in the BRCA1/BRCA2 genes have higher risk of developing breast and ovarian cancers by the age of 70. This review summarises and accesses the modelling methods, sources and quality of evidence used in the economic evaluations(EEs)/decision models on BRCA1/2-mutation testing and consequent risk-reducing strategies.

METHODS: The detailed protocol of study is registered at PROSPERO (CRD42018087775). A search for original research articles published in English from 1994 until 2018 was conducted in Medline and Embase(via Ovid), Elsevier’s Scopus, Cochrane Library, CEA Registry, HTA Database, Web of Science, and Google Scholar. Only full economic evaluations/decision models were eligible for full text review and quality assessment using Drummond and Phillips checklists. Data was analysed and summarised using descriptive statistics.

RESULTS: CONCLUSIONS: Review identified articles with various modelling methods. The results of this study can be useful for researchers constructing analytical models for BRCA1/2-mutation related health interventions.