OBJECTIVES

: To study the prevalence and risk factors of ADRs of anti-tuberculosis treatment (ATT) among TB children.

METHODS

: A prospective longitudinal study was conducted in the Sindh province, Pakistan. A total of 508 TB children in multicentre hospitals under ATT were assessed for ADRs. Naranjo causality and Hartwig’s severity assessment scale were used. In addition, various possible risk factors responsible for developing ADRs were likewise studied.

RESULTS

: A total of 105 ADRs were reported in 67 (13.2%) of 508 patients. Gastrointestinal disorders were the most frequently observed ADRs (65.7%), followed by arthralgia (24.8%). Around 65 (61.9%) of ADRs were identified as probable and 78 (74.3%) as mild severe ADRs during the study. Total 4 cases of mild hepatotoxicity were observed among children with nausea, vomiting and jaundice as the frequently reported symptoms. In multivariate analysis, the independent variables which had statistically significant positive association with ADRs were female (p =