OBJECTIVES: Among mental disorders, schizophrenia (SCZ) is the most disabling disease. The genetic polymorphisms of CYP2E1 gene are reported to be related to the development of several mental diseases. The purpose of this present study was to examine the association between the CYP2E1 (rs2070673) gene polymorphisms and schizophrenia in the Bangladeshi population. METHODS: Genotyping of this gene was done by extracting DNA from 101 Schizophrenic patients and 101 healthy volunteers, after than polymerase chain reaction (PCR) was carried out for amplification of extracted DNA. After amplification, the respective DNA fragments were digested by restriction enzyme BspMI and finally expected DNA fragments were observed by agarose gel electrophoresis technique. RESULTS: We found that patients carrying AT genotype had shown a significantly higher risk (p<0.05) for the development of schizophrenia in compared to patients carrying TT genotype. Whereas patients carrying AA genotype revealed a higher risk for the development of schizophrenia in compared to patients carrying TT genotype and this result was found statistically significant (p<0.05). For combined model i.e. patients carrying AT+AA genotype had shown a similar scenario of higher risk for the development of schizophrenia in compared to patients carrying TT genotype (p<0.05). CONCLUSIONS: So, in the context of Bangladeshi Schizophrenia patients, our result indicates that allele rs2070673 (CYP2E1*7) is associated with the higher risk of schizophrenia. As we have identified the genetic basis of the Bangladeshi schizophrenia patients, we hope it will be helpful for the treatment selection of schizophrenia patients.