OBJECTIVES: HRQOL instruments are at times used without explicit understanding of which domains are important to a given study population. The objective of the current study is to elicit an importance hierarchy among 27 previously identified HRQOL domains via a best-worst scaling (BWS) survey of the Singapore population and to identify domains that are consistently valued across different demographic groups. METHODS:   We randomly sampled community-based Singaporeans/permanent residents with pre-specified quotas for age, gender, ethnicity, presence of chronic illness, and language of interview. For the BWS exercise, we constructed comparison sets according to a balanced incomplete block design (13 versions, each with 9 choice tasks, 3 HRQOL domains per task). Each participant completed 2 versions. In each choice task, participants identified which domain is most and least important for a “happy and satisfied life”. We followed the standard analysis of best-worst object scaling (Case 1) as presented by Louviere and colleagues (Louvierre, 2010). RESULTS: Among 603 subjects (mean age: 45.2 years (SD: 16.2, Range: 21 to 88), 50.9% female;75% English language – 25% each Chinese, Malay, and Indian ethnicity; 25% Chinese language) the most important domains of health were: (Best-Worse score (B-Ws): 642), (B-Ws: 464), (B-Ws: 437), (B-Ws: 348), (B-Ws: 219), and (B-Ws: 204). Generally, the top-ranked domains were consistently valued across age, gender, ethnicity, and presence of chronic illness. CONCLUSIONS: Our study is one of the first to use BWS to elicit an importance-hierarchy of HRQOL domains. Unlike traditional ranking methods, BWS not only establishes relative importance but also the magnitude of importance.  Consistent with the World Health Organization’s framework and definition, the Singapore population’s top-ranked domains include physical, mental, and social dimensions of health.