OBJECTIVES: The burden of chronic low back pain has been researched; however, there has been no published study on the common co-morbid pain conditions associated with chronic back pain (CBP) in Western or Asian countries. We aimed to estimate the patient-related quality of life and economic impact of comorbid neuropathic pain (NeP) and/or fibromyalgia syndrome (FMS) in CBP patients at tertiary care hospital. METHODS: A cross-sectional survey was conducted in 110 enrolled CBP patients during 30 Jul 2013 – 29 Jul 2015. The developed questionnaire was consisted of patient’s characteristics, clinical and economic impact of FMS and NeP. Visual analog scale (VAS), the EuroQoL descriptive System (EQ5D), Hospital Anxiety and Depression Scale (HADS), Douleur Neuropathique 4 (DN4) and American College of Rheumatology 2010 (ACR2010). Data was collected by the face to face interview and statistical assessment was done by Stata software version 12.0. RESULTS: Among CBP patients, 29.09% were diagnosed as NeP and 19.09% were diagnosed as FMS by doctors. 8.18% of CBP patients found both of these pain comorbidities. CBP patients with NeP, FMS or both conditions experienced poorer QoL than CBP alone as the following median of EQ5D index scores: 0.51, 0.51, 0.30 and 0.59, respectively. CBP patients with NeP and/or FMS had 1-7 work days lost per month and their quality of works decreased 35-50% when pain arose. Total estimated annual productivity losses were 19,870 million baht in 2015. CONCLUSIONS: The concurrence of NeP and/or FMS among CBP patients resulted in the lower QoL, reduction in work efficiency and increasing the productivity losses.