OBJECTIVES: The combination of interferon (INF) and ribavirin is the preferred treatment for chronic hepatitis C viral (HCV) infection. However, nonresponse to this therapy remains common and is associated with several factors. The aim of this work is to determine predictors of response to INF / ribavirin therapy in chronic HCV infected patients. METHODS: The study included 110 patients with chronic HCV infection. Their ages ranged from 20-59 years. 107 liver biopsies were submitted to histopathological examination. Modified hepatic activity index (HAI) grading, modified Ishak staging, and Metavir grading and staging systems were used. Follow up HCV PCR at the 12th week to assess the early virologic response (EVR), and at the 24th week were done. HCV PCR was done at the end of the course and tested 6 months later to document end virologic response (ETR) and sustained virologic response (SVR) respectively. RESULTS: