OBJECTIVES: The utility index is important and necessary to evaluate economical aspects on cost-effectiveness analysis. There are two types of measurements to know the utility index of quality of life (QOL), comprehensive measurements and disease-specific one. For Virus Hepatitis patients in Japan, we already knew some comprehensive measurements like EQ-5D and SF-8, and also CLDQ (Chronic Liver Disease Questionnaire) for disease-specific one. However, it is not well examined the relationship among these utility indexes. Therefore we evaluate the relationship among these measurements from the patient survey. METHODS: We mailed the questionnaire include EQ-5D-5L, SF-8, and CLDQ for 4,475 hepatitis B or C patients in Japan during 10th February 2015 to 31st March 2015. The QOL utility indexes were calculated and evaluated for using correlation among two of three measurements.  RESULTS: Total 1,966 patients (Hepatitis B: 451, Hepatitis C: 1,515) answered questionnaires. Correlation coefficient between EQ-5D-5L and SF-8 PCS (physical component summary) was 0.751, correlation coefficient between EQ-5D-5L and SF-8 MCS (mental component summary) was 0.594,and  correlation coefficient between EQ-5D-5L and CLDQ was 0.731.  In addition, correlation coefficient between SF-8 PCS and CLDQ was 0.689, coreelation coefficient between SF-8 MCS and CLDQ was 0.696. CONCLUSIONS: There are strong positive correlations among these three measurements. Therefore we concluded that we can use every three measurements to evaluate the utility index to cost-effectiveness analysis for the hepatitis B and C.