DRUG UTILIZATION EVALUATION OF AMOXICILLIN-CLAVULANIC ACID IN CSOM PATIENTS IN A SOUTH INDIAN HOSPITAL: A RETROSPECTIVE ANALYSIS OBJECTIVES: To calculate the defined daily dosage (DDD) of amoxicillin-clavulanic acid in Chronic Suppurative Otitis Media patients infected with Pseudomonas spp. METHODS: A retrospective study was conducted among CSOM patients treated for three years (2012-2014). The Institutional ethics committee clearance was obtained before collecting the data from medical records. The demographics, antibiotic culture sensitivity data and the antibiotics prescription pattern of CSOM patients were collected by using case report form. The drug utilization was evaluated by calculating the DDD. The DDD/1000 people/day was calculated for amoxicillin-clavulanic acid (for both oral and parenteral preparation), using the formula:- DDD/1000 people/day = amount of drug (mg) sold in 1 year/[DDD (mg) * 365 days * no.of people] RESULTS: Among the 66 CSOM patients, 55.5% of the patients were males. CSOM tubotympanic disease was the most common type of CSOM accounting for 61.9% of the patients. Amoxicillin-clavulanic acid was prescribed in 50 patients that comprises of 75.75% of the patients. DDD/1000 people/day was found to be 25.47 in 2012, 25 in 2013 and 41.32 in 2014 for the parenteral preparation, whereas for oral preparation DDD/1000 people/day was found to be 4.30 in 2012, 15.75 in 2013 and 19.17 in 2014. CONCLUSIONS: This retrospective DUE of amoxicillin-clavulanic acid revealed that DDD has increased from 2012 – 2014 for Pseudomonas spp CSOM in this region (South India). Physicians need to adhere to antibiotic policy based on the susceptibility pattern to decrease the emergence of resistance against amoxicillin-clavulanic acid. Future, large scale studies are required to conclude the antibiotic consumption pattern in CSOM patients.