OBJECTIVES: Heamophilia A patients who receive clotting factors may develop antibodies (inhibitors) against clotting factors. The immune tolerance induction (ITI) method has proved to be a very cost-effective alternative to bypassing agents. Haemophila Foundation of India (H.F.I) Manipal chapter authorities is interested in implementing the ITI method for the management of hemophilia patients with inhibitors. The objective of this study was to calculate the breakeven point between costs attributed to the ITI method and the use of bypassing agents for the management of high- responder hemophilia patients with inhibitors. METHODS: This study assessed costs attributed to the implementation of ITI for the management of H.F.I patients with costs of high-titer and high-responding inhibitors from the perspective of the national health system. The main objective was to find the breakeven point for the ITI method in comparison with the use of bypassing medicine. RESULTS: Based on the sensitivity analysis performed, the breakeven point mainly depends on costs of factor VIII and the success rate of the ITI intervention. According to this analysis, the breakeven point of ITI  methods varies between 16 and 34 months post-treatment. The optimized point is about 17 months post-treatment.  CONCLUSIONS: H.F.I Manipal Chapter spends more than 16 Million Dollars  for providing bypassing agents to about 124 hemophilia patients with inhibitors. Because of limited resources available in H.F.I, this is a huge burden. Results of this study show that the implementation of the ITI method for the management of H.F.I Manipal chapter patients with inhibitors is a cost-saving method and H.F.I will recover all the expenditure related to the implementation of ITI in less than 2 years and will make a considerable saving along with providing standard care for these patients.