OBJECTIVES: This study aims to estimate burden of cancers attributable to tobacco smoking in ASEAN, 2012. METHODS: In this study, smoking prevalence was combined with Relative Risks (RR) of cancer to obtain Smoking Attributable Fraction (SAF). Cancer morbidity and mortality data were derived from GLOBOCAN 2012. RESULTS: The findings showed that tobacco smoking was responsible for 131, 022 cancer cases and 105,377 cancer mortality in ASEAN countries in 2012. In other words, tobacco smoking was accounted for 28.2% (43.3% in male and 8.0% in female) and 30.3% (44.1% in male and 9.0% in female) of cancer cases and cancer deaths in ASEAN, respectively. When looking at the type of cancer, lung cancer showed the strongest association with tobacco smoking. The number of cancer cases and cancer deaths attributable to tobacco smoking varied by countries due to  the different size of population, background risk of cancer, and prevalence of smoking in each country.  CONCLUSIONS: As about 30% of cancer cases and mortality in ASEAN are attributable to tobacco smoking ASEAN member countries are strongly encouraged to put in place stronger tobacco control policies and to strengthen the existing tobacco control measure in order to effectively control cancer.