OBJECTIVES: This study aims to evaluate the Health Related Quality of life (HRQoL) of patients with severe mental illness attending tertiary care public hospitals of Quetta, Pakistan. METHODS: This study was designed as a questionnaire-based cross sectional analysis among the patients with severe mental illness attending public tertiary care hospitals (i.e. Bolan Medical Complex Hospital (BMCH) and Sandman Provincial Hospitals (SPH)) of Quetta, Pakistan. Urdu version of European Quality of Life (EQ-5D) was used for assessment of HRQoL. Descriptive statistics were used to describe demographic and disease characteristics of the patients. Percentage and Frequencies were used to categorize the categorical variables, while means and standard deviations were calculated for the continuous variables. All the analyses were performed using SPSS 20.0. RESULTS: Out of all registered patients a total of 566 patients were agreed to participate and included in the study. The study population was dominated (n=330, 58.3%) by females. Majority of the respondent (n=151, 26.7%) belong to the age group 25-34 years. Having marital status as married (n=362, 63.9%) and house wife (n=321, 56.7%). A large population having no-education with 449 (79.3%) and have no-income 387 (68.4%). Majority (n=444, 78.4%) of the respondents were diagnosed with depression as major severe mental disorder. With disease duration of more than 2 years 375 (66.3%). EQ-5D mean score is 0.26±0.3 and VAS mean is 50.36±21.61. CONCLUSIONS: The study result concluded that the health related quality of life in patients with severe mental illness was poor. Further research is recommended to identify the factor associated with poor quality of life.