OBJECTIVES: HPV infection poses a substantial mortality, morbidity and economic burden especially in low – middle income countries. HPV vaccination and/or cervical cancer screening may reduce the burden of HPV-related diseases in females however, limited funds may impede the implementation of a population-based program. Governmental investments in the prevention of infectious disease may have broader economic and fiscal benefits which are not accounted for in conventional economic analyses. This study estimates the broader economic and fiscal impact of implementing HPV vaccination and/or cervical cancer screening in Indonesia from the perspective of the government METHODS: A government perspective quantitative analytic framework was applied to assess the Net Present Value (NPV) of investment on cervical cancer prevention strategies Including HPV vaccination, cervical screening and its combination in Indonesia RESULTS: Based on cohort of 10,888,500 Indonesian 12- year- old females, it was estimated that HPV vaccination and/or cervical cancer screening result in positive NPV for the Indonesian government. It was estimated that that HPV vaccination in combination with cervical screening is the most favorable option for cervical cancer prevention strategies (NPV I$2.212.310.012), followed by HPV vaccination (NPV I$2.026.113.405) and cervical screening alone (NPV I$408.584.210) CONCLUSIONS: In addition to the clinical benefits, investing in HPV vaccination and cervical screening may yield considerable fiscal benefits for the Indonesian governments attributed to lifelong benefits attributed to morbidity and mortality reduction