OBJECTIVES: The objective is to review all adverse events after immunoglobulin (IG) use and describe the characteristics of reports including seriousness and causality assessment.  METHODS: The study was cross-sectional review of adverse events related to IG from 2006 to 2015 (ten years review). RESULTS: A total of thirty-seven adverse events associated to IG were reported in ten years retrospective review.  The propotion of male:female was 1:1.3. The most adverse reactions were skin and appendages system including maculopapular rash or erythema multiforme (24%). Three out of thirty-seven were serious (pulmonary hemorrhage, septic shock and auto antibody response). Two cases were resulted in death. CONCLUSIONS: The serious adverse events associated with IG were significant from the current routine surveillance system in Thailand. Active surveillance to manage IG risk in Thai patients is decided.