OBJECTIVES: This HTA aims to evaluate the clinical effectiveness of Single Balloon Valvoloplasty  in comparison to the Double Ballon Valvuloplasty  in order to assess its results in patients suffering from Mitral Stenosis. METHODS: Health technology assessment  was conducted by systematically reviewing  the published literature . An electronic literature search was performed in Cochrane, PubMed, Journal of the American College of Cardiology  databases for randomized controlled trials. RevMan 5.3 was used for data analysis and quantitative data synthesis.  RESULTS: Out of 78 studies which were screened, 15 studies were included in the quantitative analysis (meta-analysis). In comparison to the Double Balloon Valvuloplasty Single Balloon Valvuloplasty  significantly reduced mortality  by 17 % which is indicated by  Risk Ratio (RR) 0.83 (95%CI, 0.38- 1.84). Single Balloon Valvuloplasty is found to be 4% more effective in reducing  Mitral regurgitation Risk Ratio (RR)is 0.96(95%CI, 0.74- 1.23).Procedure failure with single balloon Valvoloplasty is less indicated by Risk Ratio (RR)0.98 (95%Cl ,0.89-1.07). CONCLUSIONS: Single Balloon Valvuloplasty  is clinically effective  as far as the outcomes pertaining to the Mortality,Mitral regurgitation and Procedure failure are concerned . The burden of Rhuematic Heart Disease which thereby results in Mitral Stenosis being high therefore Single Balloon Valvuloplasty can be a potent intervention.