The Educational Symposium will present new health economic approaches for selecting which new vaccines are introduced into a country’s vaccination program. One of the new approaches is “Portfolio Management” which is a model that defines a prioritization order for vaccine introduction based on optimization of desired health outcomes within a budget constraint, supporting decision makers at a national level. Many countries currently struggle with the introduction of new vaccines due to budget constraints. This symposium will share the rationale, concepts, and real world examples of a portfolio management model developed to define specific health and economic goals to be reached by an immunization program while working under specific constraints. It has been previously applied to support decision makers from both developed and developing countries. A second approach which will be presented at the symposium is an analysis of “Return on Investment” (ROI) associated with vaccine introduction. Sustainability of vaccine programs in Latin American countries is an important issue because the level of investment dedicated for new vaccines has been increasing in recent years. ROI analysis is especially suitable for decision makers with a financial background. It has previously been applied in different countries, and presently is being evaluated for Colombia. ROI provides information on the future government revenues and expenditures associated with vaccine introduction, which is a different and complementary approach to the typical health economic analysis. In addition, a link between the two concepts described will be analyzed and presented to the audience. These concepts can improve the sustainability of vaccination programs in the Latin America (LATAM) Region. Decision makers can utilize these methods to define specific health and economic goals, which could be achieved under specific constraints, such as current budget restrictions suffering by LATAM immunization programs. This is an excellent opportunity to share the information with the ISPOR audience of the region.