OBJECTIVES::   Tuberculosis is a one of the most contagious disease in the world. The number of patient of tuberculosis is increasing enormously day by day. The so rapid increase is associated with some particular risk factors that are responsible for it. The objective of our study was to identify the particular risk factors that are responsible for its spread and fully eradicate from the world. METHODS::   Retrospective study was conducted from in punjab Pakistan to identify the risk factors of the tuberculosis. A structured questioner was prepared to conduct the interview with the patients. The questioner consist of anticipated risk factors that are responsible for discontinuation of tuberculosis treatment i.e. duration of treatment, misconceptions and false belief, poverty and malnutrition, herbal medicines, literacy, patient compliance and smoking. Among the hospitals of punjab, almost 2500 patients were considered to identify the risk factors of tuberculosis. RESULTS::   In this study there were 2500 subjects under consideration, among these 2500 patients, 1680 were males that accounts for 67.2% of total suspects and 820 females that is 32.8% of total subjects. The percentage of different risk factors are in the following ratio. HIV 1.6%, not aware of duration of treatment 68.8%, not aware of ADRS 26.8%, misconceptions 9.2%, poverty and malnutrition 90.8%, herbal medicine 15.2%, illiteracy 66.4%, smoking 23.2%, lack of DOTS therapy 76.4%. CONCLUSIONS::   Tuberculosis is a highly contagious disease. We have concluded that HIV, not knowing about the duration of treatment, person that are not aware of ADRS, poverty, malnutrition, person taking herbal medicine treatment, those who are illiterate, smokers and those having severe condition and not having DOTS therapy are at high risk of getting this infection. There are still many other important factors according to studies conducted in recent years. But in Pakistan we have to minimize these factors to overcome this disease.