OBJECTIVES:: To evaluate the Health-Related Quality of Life of elderly patient using teriparatide (TPTD) METHODS:: A prospective observational study from April 2006 to February 2014 was carried out with 77 patients in a district Spanish hospital. The Health-Related Quality of Life of Patients (HRQoL) was assessed using the European Quality of Life Questionnaire (EQ-5D) before and after the TPTD therapy.A descriptive and regression analysis was done for assessing the data. RESULTS:: Mean age of patients was 75,3 years (standard deviation, SD = 7,1 years); 4,1% were male. HRQoL of patient treated with TPTD improved from 0.36 to 0.58 EQ-5D score. The mean VAS improved (from 5.42 to 3.47), OR (2.021 to 1.695). In 80% of the patients a reduction of pain was observed as well as a reduction of fracture. CONCLUSIONS:: TPTD improved the HRQoL of patients studied, this data obtained can be used for cost-utility ulterior analysis.