OBJECTIVES:: Assess varicose great saphenous vein treatment alternatives comparing SoC vs radiofrequency ablation, through health economic evaluation into the healthcare public institutions at Mexico METHODS:: Health economic evaluation was designed under cost-minimization analysis to compare Stripping vs Radiofrequency Ablation-RFA (Closure Fast ^®) considering total cost per patient. Previously a systematic review and its meta-analysis were executed to demonstrate similar efficacy (assessed through neovascularization, recurrence, technical failure and recanalization). We took into the account the mean cost per patient (medical direct costs associated with each alternative). The healthcare resource pattern was collected using DRG (released by the own healthcare public sector at Mexico). The base case analysis considered for RFA costs: catheter, generator and stiletto. The generator has been offered under lending contracts. The results were estimated on US dollars (exchange rate, 2017: 1dlls – 19.08 MXN pesos): total cost per patient for each alternative. RESULTS:: Derived from systematic review and its meta-analysis, we did not find statistical difference between alternatives. The cost per patient under SoC was $1,213.00 dlls and considering RFA under lending contract the cost per patient was $ 986 dlls (without inpatient day, where the vast majority of the patients fall) and $1,632 dlls (considering an inpatient hospitalization day, which is not the rule for patients under RFA treatment) . We executed sensitivity analysis (uni, multivariate and probabilistic), and the results were consistent with the base case scenario. Finally the budget impact analysis considered a hypothetical incremental market share vs SoC (stripping) into the healthcare public institutions (50, 75 and 100%). So, the budget impact oscillates between 0.002% and 0.27% depending on the scenario and healthcare institution. CONCLUSIONS:: Choose RFA (Closure Fast ®) bring to the patients not only clinical outcomes, besides better QoL and aesthetics results, achieving lesser post-surgical pain and offer "value for money" into the Mexican context.