OBJECTIVES:: To understand the burden of Chronic Heart Failure (CHF) on caregivers in Mexico. METHODS:: A Disease Specific Program was conducted to assess the impact of CHF in Mexico. Data was made available through cardiologist-completed patient record forms, and patient and caregiver self-completion (CSC) questionnaires. RESULTS:: CSC questionnaires revealed that a typical caregiver (n=98) was female (60%) with a mean age of 53.1 years. Caregivers spent approximately 37 hours per week caring for the patient. Eight in ten patients lived with the caregiver, and the main caregiver was often the patients’ spouse (46%) or daughter/son (33%). Caregiver Activities: The most frequently reported tasks were providing emotional support/encouragement to patients (76%), and reminding them to take their medication (72%). Caregivers most frequently asked doctors about diet/lifestyle (78%) and treatment (68%) for the patient. Emotional Burden:  29% of caregivers reported a decrease in social activities due to caregiving. As a result of caring for the patient, 41% of caregivers suffered from stress and 33% from anxiety. Financial Burden: One in six caregivers reported a reduced income from a change in job or reduction in working hours due to caregiver responsibilities. Additionally, 89% of caregivers did not receive financial assistance from the health care system or social services. Nearly 20% of caregivers reported paying an average of $98 per month for the patient’s CHF prescriptions, and 5% covered all the cost for rehabilitation, an average of $109 per month. Ten percent of caregivers paid a mean of $454 per month for hospitalizations. Travel: On average, caregivers accompanied the patient 6 times per year to CHF appointments, and 30% of caregivers paid a mean of $58 per month for travel costs. CONCLUSIONS:: These data are significant for understanding the impact of CHF for patients’ caregivers, and extrapolating its impact to the greater Mexican population.