OBJECTIVES: Primary Objective: – To study prescription pattern of antibiotics as prophylactic and in post surgery infection.  Secondary objective: – To determine antibiotic sensitivity pattern in bacterial isolate METHODS: The study was a prospective study for a period of four month from Jan-May 2013, Prescriptions and patient records files are reviewed and analyzed. Prescription pattern and antibiotic sensitivity was also evaluated. RESULTS: Total 154 patients were included in our study from these 59% were male (n=91) and 41% were female (n=63). Total 19 different antibiotics were prescribe in general surgery in which Amikacin (n=106, 69%), ceftriaxone (n=104, 67%) and metronidazole (n=72, 47%) are most commonly prescribed antibiotics. Most of the patient had undergone hernioplasty surgery (n=33, 22%) followed by Incision & Drainage (n=23 15%), debridement (n=21, 14%), Appendicectomy (n=16, 10%). Pus swab culture (44%) are done most frequently followed by wound culture (n=13, 24%), urine culture (n=9, 17%) in culture and sensitivity test. Most common isolate were klebsiellia sp. (n=12, 31%), followed by S. aureas(n=9, 21), E. coli (n=8, 19%) which are resistant to ampicillin, amoxicillin, carbenicillin, ceftriaxone, cefuroxime, ceftazidime and cefotaxime and sensitive to levofloxacine, gatifloxacine and amikacin.  CONCLUSIONS: There was high tendency to prescribe the 3rd generation cephalosporins. Physicians prescribed ceftriaxone antibiotic as prophylaxis for hernioplasty, appendectomy and Lap. Cholecytectomy. Most of the patients admitted to surgery unit had received antibiotic without regard to Culture Sensitivity report and standard guidelines. E. coli isolates were found to be 100% resistant to all penicillins, 3rd generation cephalosporins, cotrimoxazole and amoxiclav and Klebsella species were found to be 100% resistant to ampicillin.