OBJECTIVES: Half of the world’s population is estimated to be infected with Helicobacter pylori (H. pylori), a bacterium shown to be linked with a series of gastrointestinal diseases. A growing number of systematic reviews have been published comparing the effectiveness of treatment regimens in the eradication of H. pylori, but have not reached a consistent conclusion. This study provides an overview of systematic reviews of pharmacological therapies for the eradication of H. pylori.  METHODS: We searched major electronic databases from 2002 to 2013. Studies were considered eligible if they included RCTs comparing different pharmacological regimens for treatment of patients diagnosed as H. pylori infected and pooled the eradication rates in a meta-analysis. A modified version of ‘A Measurement Tool to Assess Systematic Reviews’ (AMSTAR) was used to assess the methodological quality. Where appropriate, network meta-analysis of proton pump inhibitors (PPI) or antibiotics within treatment regimens was conducted.  RESULTS: