OBJECTIVES: COPD is known as a disease with irreversible progress but preventable and managable. In Korea, COPD was ranked 12 with 242 DALYs(per 100,000) following diabetes(970 DALYs), cerebrovascular diseases(937DALYs) and asthma(709 DALYs). Health-related quality of life in COPD patients has not been investigated in Korea. METHODS: Data of Korean National Health and Nutrition Examination Survey(KNHANES) 2007-2012 were used. According to the GOLD criteria, we classified COPD patients into I-IV grades. EQ-5D index score were analysed by the severity of COPD and Comorbidities. Wilcoxon rank-sum test were used to compare quality of liife in COPD patients with that of the general population. SAS 9.3 version was used for analysis. RESULTS: : Utility score for the general population was 0.9291±0.1320 while COPD patients were scored 0.9042±0.1478 showing a significant difference(p<0.0001). Comorbidities demosntrated a significant impact on the quality of life among COPD patients. Patients with hypertension(0.8863±0.1574), diabetes(0.882831±0.169179), cancer(0.8675±0.1691), and depression(0.8089±0.1784) showed a significantly lower utility score that those without comorbidities(p<0.0001, p=0.0042, p<0.0001, p=0.0687, respectively). According to the severity, mild(0.905754±0.140629) and moderate(0.9090±0.1465) COPD patients had a similar EQ5D index score. However, severe(0.8722±0.1724) and very severe(0.6816±0.2705) stages showed a significantly lower quality of life. We also found that diagnosed rate among COPD patients was only 2.96%. CONCLUSIONS: As severity of COPD has shown a great impact on quality of life, preventable strategy and management should be developed. Especially early diagnosis and early detection will be the first step to take for COPD management in South Korea. To do so, interdisciplenary approach should be made.