OBJECTIVES: Atopic dermatitis (AD) is a chronic skin disease typically presenting in infancy. A literature review was conducted to identify pediatric AD cost estimates in Asia-Pacific (AP) countries. METHODS: An electronic literature search was conducted in PubMed, Google scholar, and Asian electronic reference databases to identify studies reporting on pediatric AD cost estimates in AP countries. Open text search terms were used to maximize the sensitivity of the search strategy. These searches were supplemented by manual reviews of bibliographies of the articles reporting cost estimates and discussions with AD experts. Costs were inflated and converted to 2013 US dollars. RESULTS: Annual AD costs per patient were identified in Australia (cross-sectional survey of 48 parents of AD children; age 4 months-15 years; total costs for all, mild, moderate, and severe cases: $2,745; $925; $3,301; $4,907, respectively; direct costs only: $1,400; $636; $1,577; $2,420, respectively), South Korea (cross-sectional survey of 196 parents of AD patients; age <12 years; visiting an allergy clinic; total: $3,522; direct: $1,253); Indonesia (model-based; age 0-6; urban; total: $743; direct: $740), Malaysia (model-based; age 0-6; urban; total: $576; direct: $398), Philippines (model-based; age 0-6; urban; total: $371; direct: $363), Singapore (model-based; age 0-6; urban; total: $1,097; direct: $957), and Thailand (model and chart review of 3,502 AD children; age 0-5; direct costs; all, mild, moderate, and severe AD: $199, $124 $415, $968, respectively). CONCLUSIONS: The economics of pediatric AD in AP has not been extensively studied. Based on available evidence, annual pediatric AD costs are generally high. Variations in cost estimates are due to between-study differences in country of analysis, types of costs included, severity of AD, and costing methodology. Further evaluations of the AD costs and the cost-effectiveness of pediatric AD prevention strategies in AP countries are warranted.