OBJECTIVES: To determine the trend of drug utilization for Alzheimer’s disease during 2009 and 2013. METHODS: Prescription data of outpatients with Alzheimer’s disease in 2009 – 2013 was extracted from the medical care database of the hospital. Quantities and costs of the prescribed drugs were examined using defined daily dose (DDD) for comparisons. RESULTS: Number of patients was rather the same number every year ranging from 1,507 to 1,631 patients. For donepezil and memantine, number of DDD per year was increased every year ranging from 7.3–10.0 % to 1.6-14.7% compared to the previous year, respectively. The increasing trends were not found in prescribing of rivastigmine, except for the dramatically increase (34.0%) in 2013. Galantamine was prescribed less in 2010 and 2013 accounted for -9.2 and -18.2%, respectively. Cost of drug use in Alzheimer’s disease was $3,211,269 in 2009 and $3,228,454 in 2013 with an increasingly trend. CONCLUSIONS: The overall drug use in Alzheimer’s disease seems to be a heavy burden of the hospital every year. The rational drug use should be confirmed to make sure to guarantee appropriate use of drug without overusage.