OBJECTIVES: To describe the drug utilization pattern in the treatment of patients with septic shock in the ICU. METHODS: Setting: 7-bed mixed medical/surgical intensive care unit (ICU) of a tertiary care teaching hospital.A retrospective cohort study of patients with septic shock, who were treated in the ICU between January 2012 and December, 2013. The ICU database was used to identify the patients. The patient demographics and characteristics were recorded. In addition, the number and type of prescribed medications, type of infection, and culture results were determined. The main outcomes were the type of medication classes utilized and their comparison between the survivors & non-survivors. RESULTS: During the study period, 109 cases were identified. Upon presentation, the mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 22.5 (SD ±7.8), 93 (85.3 %) patients had leucocytosis, and 84 (77.0 %) had positive cultures. The mean number of medications prescribed per patient was 11.7 (SD ±4.7). The most commonly prescribed medication classes were proton pump inhibitors, carbapenems, BL/BLI combinations and vasopressors prescribed in 101 (92.6 %), 75(68.8 %), 64(58.7 %), and 91(83.4 %) patients, respectively. Antifungals and blood products were prescribed in 45 (41.2 %) and 77 (70.6 %) patients, respectively. Medication usage were higher in non-survivors, compared to survivors (12.6 ± 2.4 versus 9.7±4.1), and in patients with positive cultures (13.5±1.9 versus 9.3± 3.6) compared to patients with negative cultures. CONCLUSIONS: In patients with severe sepsis and septic shock, multiple medications were prescribed, and the use of medications was higher in the non-survivors in comparison to the survivors.