OBJECTIVES: To evaluate the accuracy of different blood glucose determination methods, and provide a theoretical basis for governments to determine the mainstream glucose detection methods. METHODS: The MEDLINE, EMBASE, EBM REVIEWS, CBM, CNKI, Wanfang, Google academic search et al were were retrieved for literatures collection, literature quality evaluation was implemented by using QUADAS criteria, meta-analysis was carried out using Stata11.0 and  heterogeneity test and sensitivity analysis was implemented. RESULTS: CONCLUSIONS: there was significant difference between different blood glucose detection methods; application of dry chemical measurement results should be cautious, we recommend using the glucose oxidase or diagnosis hexokinase method.