OBJECTIVES: Alzheimer’s disease (AD) is a chronic and progressive disease that is a significant burden on caregivers. Research indicates AD caregiver burden on health status; but there is limited research on caregiver burden in Japan. The objectives of this study were to examine Japan AD caregiver burden vs. Japan non-caregivers and 5E.U. AD caregivers. METHODS: Data were obtained from the 2012 Japan (N=30,000) National Health and Wellness Survey (NHWS) and 2013 5E.U. (UK, Germany, France, Italy, Spain; N=62,000) NHWS, administered online to a representative adult sample (18+ years). Respondents reported on health status (SF-36v2), activity impairment, healthcare utilization in the past six months and caregiver responsibilities. Multivariable regressions, adjusting for demographics and health history variables to explore differences between Japan AD caregivers (n=714) vs. Japan non-caregivers (n=27,702) and 5E.U. AD caregivers (n=1,239). RESULTS: Japan AD caregivers were older and reported more depression symptoms than Japan non-caregivers (p<0.05). Japan AD vs. 5E.U. AD caregivers were older and more educated (p<0.05). After adjustments, Japan AD caregivers had lower health status (p<0.001), higher healthcare utilization, and greater activity impairment (p<0.001) than Japan non-caregivers. Japan AD vs. 5E.U. AD caregivers had better mental (45.7 vs. 43.8, p<0.001) and physical (51.0 vs. 50.0, p=0.021) health status, marginally less activity impairment (24.5% vs. 27.1%, p=0.070), but more healthcare provider visits (7.6 vs. 5.4, p<0.001) and hospitalizations (p<0.001). Japan AD caregivers vs. 5E.U. caregivers were less likely to make treatment decisions and manage finances for AD relative (p<0.001), were marginally less involved in helping with daily activities (transportation, meals, shopping, p=0.054), but no difference was found on bathing/grooming involvement. CONCLUSIONS: Japan AD caregivers report more burden including more depression symptoms than Japan non-caregivers. Japan AD caregivers report greater healthcare utilization than 5E.U. AD caregivers, but report better health status, and less involvement in treatment and finance decisions.