OBJECTIVES: Health economics and outcomes evaluations has become an indispensable tool to guide decision-making processes regarding incorporation of new technologies. Since 2009, with the publication of methodological guidelines by REBRATS, followed by creation of the National Committee for Health Technology Incorporation (CONITEC), in 2011, health economics research are emerging in Brazil. Therefore, the aim of this study is to evaluate temporal trends and main areas of interest in scientific production in these fields by a bibliometric analysis. METHODS: A search in the ISPOR Scientific Presentations Database was performed, using the term “Brazil” as keyword search in “Abstract” field, evaluating all results between 1998 and 2014. Abstracts were classified according to study characteristics (topic and subtopic), sponsorship and disease area.  RESULTS: Among the total of 29,759 abstracts available in ISPOR presentation database, only 716 (2.4%) mentioned the term “Brazil” in the abstract, of which 169 (23.6%) the first author was not from Brazil and 325 studies (45%) were sponsored by pharmaceutical companies. Up to 2006, scarce publications were found. The majority of the studies (62.6%) was published from 2012 to 2014. The most studied diseases were cancer (16.9%), infection (5.9%), GI disorders (3.9%) and diabetes (3.1%) and 14.5% classified as “no specific disease”. In addition, 57.3% of the analyses were classified as “cost studies” and 24.1% as “Health care use & policy studies”. According to the subtopic, 140 (19.6%) were cost-effectiveness analysis and 73 (10.2%) budget impact analysis.  CONCLUSIONS: This analysis showed a low rate of publication related to Brazil. On the other hand, the increasing number of published studies from 2012 may be related to CONITEC foundation. Thus, the rising number of studies observed over this period indicates an increase in importance of health economics as a support for health polices development and decision making process