OBJECTIVES:  Ileocolic anastomoses are performed for right-sided colon cancer and Crohn’s disease. Anastomotic leak complications are a significant source of patient morbidity and mortality and may have a major impact on health care costs. Prior studies (e.g. Choy PYG, 2011 Cochrane Review) have estimated a significant reduction in post-operative leak rate following stapled anastomosis creation versus sutured (2.49% vs. 6.14%). The objective of this analysis was to assess whether the clinical benefit also reflected an economic benefit for right colon resection surgery. METHODS:  A budget impact model was developed to compare intraoperative and post-operative costs of right colon surgeries using either a hand-sewn sutured approach or a stapled approach to anastomosis creation. Cost inputs to the model included intraoperative material costs (stapler, linear cutter, reloads and sutures), operating room and anesthesia time cost for creation of anastomosis, overall surgery and readmission costs. Other inputs included time for anastomosis creation and anesthesia, post-operative leak rate and reoperation rate. Sensitivity analyses were performed for all relevant variables. Budget impact was calculated on an annualized basis of 100 surgical procedures. As initial analysis, local pricing and cost data were used for Brazil SUS, with a goal of expanding the analysis to other Latin American countries subsequently. All currencies were converted to US$ for ease of comparison across countries. RESULTS: A substantially favorable annual budget impact was demonstrated for Brazil, with an annual savings of $33,136.00 for the hospital, which was equivalent to a $331 savings per patient. The economic value was primarily driven by lower reoperation rates. Further data are being collected to assess similar budget impact in selected Latin American countries. CONCLUSIONS: The clinical benefit of stapled anastomosis creation of right colon resection surgery is expected to be accompanied by a strong potential economic benefit – as estimated for hospitals in Brazil.