OBJECTIVES: To compare the economic, public health, and humanistic impact of a quadrivalent (HPV6/11/16/18) vaccination program in a two-dose scheme for 9-11 year old females with a bivalent (HPV 16/18) vaccination program in Mexico METHODS: A previously developed transmission dynamic mathematical model was adapted to evaluate the impact of routine vaccination of 9-11 year old females in Mexico. The model compared baseline coverage of 70% for two doses of the quadrivalent vaccine versus bivalent vaccine. Mexico specific data was used from literature where available; default values were used otherwise. Input data included demographic, behavioral, epidemiological and screening parameters, and direct treatment costs of HPV-related morbidities from a public health perspective. RESULTS: In a 100-year period, as compared to a two dose 70% bivalent vaccination program, a 70% quadrivalent vaccination program coverage would result in reductions of HPV 6/11-related disease incidence at the population level as follows: genital warts in females (83%), genital warts in males (81.4%) and HPV6/11-related CIN1 (82%) . This would translate into a reduction of HPV 6/11-related disease cost of 59.1%, 56.3%, and 55.7% for genital warts among females, genital warts among males, and HPV6/11-related CIN1, respectively.  Under the model assumptions, over a 100 year period, the total HPV6/11/16/18- related disease costs avoided would be over $1.7 billion Mexican Pesos. Thesincremental cumulative QALYs gained per 100,000 by HPV 6/11/16/18-related disease over 100 years would be 30.31 when compared with an HPV16/18 vaccination program. CONCLUSIONS: In Mexico, routine vaccination of 9-11 year old females with a quadrivalent HPV6/11/16/18 vaccine has incremental economic, public health, and humanistic impact as compared to a bivalent HPV 16/18 vaccine.