OBJECTIVES: Previous research has shown that workplace-based smoking cessation programme (WPSCP) is cost beneficial to employers due to improved productivity of employees. Yet, the number of companies in Singapore that support or provide WPSCP is limited. This study aims to identify gaps between evidence (i.e. interventions shown to be effective) and practice, which is employers’ perceived effectiveness and feasibility of interventions for WPSCP. Further, we seek to evaluate employers’ willingness to implement specific interventions within their workplace. METHODS: One to one semi-structured face-to-face interviews with employers in Singapore were conducted from August till November 2011. Employers were asked to give their views on what they could do to help their employees quit smoking. Response options for feasibility and willingness to implement were yes/ no/ don’t know or unsure. Employers also rated the effectiveness of various interventions within the workplace as not at all effective/ quite effective/ moderately effective/ very effective/ don’t know or unsure.   RESULTS: Representatives from 40 companies were recruited. Most of the employers rated smoking cessation talk as moderately effective (n=20, 50%), followed by smoking cessation aids (n=16, 40%). The three interventions with the most number of employers judging them as feasible were smoking cessation posters (n=30, 75%), smoking cessation talks (n=29, 72.5%), and contests to help smokers quit (n=28, 70%). Majority of the employers are willing to disseminate posters within the workplace (n=32, 80%) or offer smoking cessation talks (n=31, 77.5%). In contrast, employers did not support group counseling and pharmacological treatment although they were shown in a Cochrane review to have strong evidence of efficacy within the workplace. CONCLUSIONS: Interestingly, interventions shown to be effective in experimental settings were not supported by employers and they were unwilling to implement these strategies. This gap between evidence and practice needs to be addressed, possibly through employer education.