OBJECTIVES: To evaluate the 10 year utilization trends of antiepileptic drugs (AEDs) in Iran METHODS: Annual pharmaceutical sales data were acquired from the Ministry of Health (MOH). To express data, Anatomical Therapeutic Chemical (ATC) classification and Defined Daily Dose (DDD) as described by WHO collaborating centre for drug statistics methodology were used. DDD/1000 Inhabitants/Day (DID) was the main unit for measuring drug sales and N03 was considered as AEDs here.  RESULTS: Between 2000 and 2010, the total consumption of antiepileptic drugs increased by 49.85%, and reached 8.7  DDD/1000 inhabitants/day in 2010. Within the studied ten years, the consumption of old AEDs increased by 9.6% (6.37 DDD/1000 inhabitants/d ay in 2010), while in the case of new AEDs the increase was 11432% (2.37 DDD/1000 inhabitants/day) CONCLUSIONS: A significant shift can be seen in the consumption of new AEDs. This change is partly due to the improved efficacy of these drugs compared to the older types and referable to new indications to some extent.