OBJECTIVES: To assess co-morbidity, quality of life (QOL), work/productivity loss, and medical resource utilization (MRU) in patients with Ankylosing Spondylitis (AS) in urban China. METHODS: Patients’ self-reported data were collected from 2010 National Health and Wellness Survey (NHWS). This survey represents urban population 18 years and older. QOL was measured by the physical component score (PCS) and mental component score (MCS) of the Short Form-12 (SF-12). Loss of work/productivity was measured by the validated Work Productivity and Activity Impairment (WPAI) instrument. MRU was measured by traditional healthcare provider, emergency room (ER) visits and hospitalization in the past 6 months. Comparisons were made between respondents who reported as diagnosed with AS (excluding other auto-immune diseases) vs. respondents without AS (non-AS group). RESULTS: Of 19,954 survey respondents, 52 (0.26%) were diagnosed with AS. The average age was 43.0 (SD 13.5) years with 57.7% of males. AS group reported higher Charlson comorbidity index score than in non-AS group (1.4 vs. 0.2). The most common comorbidities (>25% of patients) were headache, insomnia, gingivitis, body pain, sleep difficulties, arrhythmia, anxiety and arthritis. AS group had lower mean scores of PCS (42.9 vs. 49.6) and MCS (44.1 vs. 46.2), more patients visited health care providers (71.2% vs. 49.7%), ER (30.8% vs. 17.6%) and hospitalized (19.2% vs. 5.7%) in the past 6 months vs. non-AS group. Also, AS group reported more work productivity loss (absenteeism/presenteeism) with 40.1% vs. 23.3% and impairment in daily activity with 36.7% vs. 20.3% in non-AS group. All comparisons between AS and non-AS groups were statistically significant at P<0.05, except MCS. CONCLUSIONS: From the China NHWS results, AS patients suffer from impairment in quality of life, work/productivity loss, more co-morbidities and use of medical services. The findings indicate there is still an unmet medical need in AS patients in China.