OBJECTIVES: Drug-induced skin  reactions (DISR) may be a serious medical problem, and economical in every country METHODS: The aim of the study was to analyze the direct costs (costs of medication, laboratory costs, costs of physician visits) of 164 patients (57M, 107 W, mean age 53.7years) hospitalized in the Department of Dermatology, Military Institute of Medicine, Poland between 2002 -  2012 due to  DISR  from the public payer (NHF) and hospital perspective. RESULTS: In the group of the most common forms of DISR  there were toxic - allergic dermatitis (n=85) and erythema multiforme (n=41). The most common cause of drug-induced skin reactions were beta lactam antibiotics, cephalosporins and NSAIDs. Symptoms of DISR appeared on an average after 7.4 days of treatment. The average hospital stay was 4.54 day per patient. Direct average cost of treatment from the NHF perspective was 717€ per patient and from the hospital perspective was 680 € per patient. CONCLUSIONS: Treatment of DISR  is expensive, but well priced by the public payer in POland