OBJECTIVES: Health technology assessment in Latin America has been relatively more mature than other similarly developed health systems. This research explores the trends of development of HTA in the region to understand similarities to the European HTA model. It further looks at relevance of having such a model in Latin America, the relevance of the complexity of the methodologies and utilities used and finally, the implications of these trends. METHODS: The study was conducted in Brazil, Mexico, Argentina and Columbia. Opinions of 18 stakeholders were collected via telephone interviews. Respondents included senior clinical oncologists(3), academics(4), policy advisors(2), senior bureaucrats in the health ministries(3), senior members of HTA bodies(4) and senior executives from manufacturers(2). A scoring system was devised to plot the level of complexity and maturity of the HTA systems / agencies both in Latin America and then comparing it with scores of a similar study across Europe and Australia. The responses around the relevance of the model and implications were analysed qualitatively adding perspective from the author’s experience in these countries. RESULTS: The level of maturity of HTA processes in all the countries studied was seen to be generally high. The level of association with reimbursement processes was seen to vary. There was a split on the relevance of the European model to the Latin American context. Majority of the academics (n=3/4) and members of HTA bodies (n=2/4) felt that following highly complex European models was a necessary natural progression to the HTA development curve. This was not the observation with the rest of the stakeholders. CONCLUSIONS: There is thought to be a trend where there is a push by academics and HTA-related professionals towards making it similar to the European model, and thus increasingly complex. Greater international attention can be a reason, although it must be further explored.