OBJECTIVES: Drugs of first choice in the treatment of hypertension are: β-blockers, tiazide diuretics, ACE inhibitors, angiotensin receptor inhibitors and Ca channel blockers. The aim of this study was to analyze the consumption of antihypertensive drugs in Serbia in the period from 2007 to 2011 year. METHODS: The data about the use of drugs were taken from the Agency for Drugs and Medical Devices of the Serbia. RESULTS: The use of diuretics during the observed period in Serbia is quite small and it ranged from 5 to 6% of the total consumption of all drugs from the C group. Consumption of β-blockers was around 12% during all 5 years. Consumption of calcium channel blockers was less than 12% of the total consumption of all drugs from group C in the first 2 years of the observed period. However, consumption of such drugs in the last 3 years  growing over 18% of the total consumption of all drugs from the C group. Total consumption of drugs acting on the renin-angiotensin system (C09) in Serbia in opserved period was over 41 % of the total consumption of all drugs from the C group. The highest percentage in this group belonged to the ACE inhibitors. Consumption of angiotensin receptor inhibitors is small and it is only a few percent of the total consumption of all drugs from C09 group. However, consumption of drugs in this subgroup recorded steady growth in recent years. CONCLUSIONS: In Serbia in the observed period, ACE inhibitors are the most frequently used drugs within the group of drugs which is used for treatment of hypertension. This research was supported by Provincial Secretariat for Science and Technological Development, Autonomous Province of Vojvodina project No 114-451-2458/2011 and by Ministry of Science, Republic of Serbia, project no 41012.