OBJECTIVES: Through symptom survey in cancer patients to find out the symptom distribution and patients treatment require. Also validate set of symptom items that are most commonly used in Traditional Chinese Medicine (TCM). METHODS: Use M.D.Anderson Symptom Assessment Inventory (MDASI) that previously validated Chinese version. Add 10 TCM items. We also asked the questions about using TCM request in cancer care. A multi center cross-sectional study using a convenience sample of 340 patients were conducted in 3 hospitals in Beijing and Dalian. Statistical use Spss and Excel software. Self evaluate questioner with Cronbach’s Alpha score. RESULTS: The most severe symptoms were fatigue 89.4%, sleeping disturbance 74.4%, moth drier 72.9%, and poor appetite 72.9%, forgotten 71.2%. The influence of cancer symptoms to work, mood and activity were 89.7%, 82.6%, 78.6% separately. The quality of life was affected severely. 80% patients want to regulate the body with TCM. Almost 100% patients hope to know the knowledge of integrated TCM and western medicine, and the effect of TCM treatment cancer and health recover. Cronbach’s Alpha score indicated acceptable internal consistency both the MDASI and TCM items, 0.86 for MDASI, 0.78 for TCM, 0.9 for MDASI_TCM 23 items. CONCLUSIONS: Fatigue, sleep disturbance, moth drier, poor appetite and forgotten are more severe symptoms in our cancer patient’s survey. Greatly affect the quality of life of patients. There are an extremely request that TCM holism regulation in cancer patients. The MDASI and its TCM model could a critical tool to measure the effectiveness of TCM in cancer symptom management.