Chile’s health indicators are good compared with other Latin American countries with similar gross national product. Nonetheless, disparities in health care services are not absent in Chile. OBJECTIVES: The aim of this study was to evaluate satisfaction with primary health care and health-related Quality of Life (hrQoL) between patients in urban and rural areas of Chile. METHODS: A national-representative sample of 1544  patients was surveyed at 38 primary care centers. The “Encuesta de expectativas, percepcion y satisfaccion usuaria con modelo de salud familiar” (survey of patient expectations, perception and satisfaction with the family health model) and the EQ-5D questionnaire were administered to assess patient satisfaction level, and self-evaluated health, respectively. Using the Chilean social value for reported health states, a mathematic equation was used to compute the average hrQoL. RESULTS: Patient satisfaction was 5.28 ± 0.30 (scale 1 to 7). There was a statistically significant difference between urban and rural areas (5.45 ± 1.06 and 5.10 ± 1.28 points, respectively). The mean hrQoL for the entire population was 0.77 ± 0.00 (scale 0 to 1), with a statistical significant difference between rural and urban areas (0.78 ± 0.24 and 0.75 ± 0.25, respectively). Using stepwise multivariate regression we were able to explain 25.4% (R2=0.254) of the variability in patient satisfaction. Length of consultation with the health care professional (Beta = 0.215, p value <.001), patient education level (Beta = -0.115, p value = 0.006), and year in which the center was founded (Beta = 0.089, p value = 0.025) were identified as explanatory variables.   CONCLUSIONS: Despite evaluating better-perceived quality of health services, urban patients rated lower their self-assessed health. These results should motivate policy makers in looking for innovative ways to diminish the gap in quality between urban and rural areas.