OBJECTIVES: This study aims to determine the significant factors affecting willingness- to-pay (WTP) for the treatment of blindness in Thai population. METHODS: A cross-sectional survey using a semi-structured questionnaire was conducted during December 2007 – January 2008. In this study, 118 persons who resided at Pathumthani province were interviewed. Inclusion criteria included; 1) aged between 15 – 65 years, and 2) able to imagine the contingent scenarios. Those who had blindness condition or who were not willing to collaborate in the study were excluded. Willingness- to-pay amount was assessed using bidding method with the range starting from 5,000 Baht to 300,000 Baht. The participants were asked about the amount of money they would pay for the treatment of unilateral blindness and bilateral blindness, respectively. Binary logistic regression and linear regression analyses were performed to determine the significant factors affecting WTP. RESULTS: The result revealed that approximately 72.03%, and 84.75% of the participants indicated that they would pay for the treatment of unilateral blindness and bilateral blindness, respectively. Using a binary logistic regression analysis, starting point of bidding (OR=0.99, P-value = 0.04) was a significant factor affecting WTP in unilateral blindness treatment scenario. On the other hand, age (OR=0.9, P<0.01) was a negative significant factor affecting WTP for bilateral blindness treatment. Among those who indicated that they would pay for treatment, the result from linear regression analysis showed that household income (β =0.21, P= 0.03), current health utility ( β = 0.23, P= 0.02), and level of education (β = 0.52, P<0.001) positively affect the willingness-to-pay amount for treatment of  bilateral blindness. CONCLUSIONS: According to the study, about 72.03% and 84.75% of the people indicated that they would pay for treatment of unilateral blindness and bilateral blindness. Starting points of biding and ages were significant factors affecting WTP for treatment of blindness while income, current health utility and level of education positively associated with willingness to pay amount for treatment of blindness.