OBJECTIVES:  This study evaluated effects of sirukumab, a selective anti-IL-6 cytokine monoclonal antibody, on work productivity/interference and health status in patients with active rheumatoid arthritis (RA) despite treatment with anti-tumor necrosis factor (TNF) therapy. METHODS:  In this randomized, double-blind, phase 3 trial, 878 eligible patients with active RA who were intolerant/refractory to anti-TNFs were randomized 1:1:1 to sirukumab subcutaneous (SC) 50mg every 4 weeks (q4w; n=292), sirukumab SC 100mg every 2 weeks (q2w; n=292), or placebo SC q2w (n=294). At Week 18, placebo patients were re-randomized to 1 of the sirukumab doses if insufficient (<20%) improvement; at Week 24, all patients remaining on placebo crossed over to sirukumab. The Work Limitations Questionnaire (WLQ) evaluated health-related job limitations and productivity loss in 4 domains (mental-interpersonal, output, physical demands, time management); the 3-level EuroQol-5 Dimension (EQ-5D) questionnaire measured 5 dimensions of health status (mobility, self-care, usual activities, pain/discomfort, anxiety/depression). RESULTS:  At Week 24, mean total WLQ scores improved significantly from baseline for sirukumab 50mg q4w and 100mg q2w versus placebo (mean change, –2.2 and –2.3 vs 0.2, respectively; both p<0.001), as did all 4 mean WLQ domain scores (all p≤