OBJECTIVES: "De Todo Corazón" (DTC) is a cardiovascular risk management program. The aim of this study was to estimate the transition probabilities of Chronic Kidney Disease (CKD) in patients under program care. METHODS:  We followed up a cohort of 55,915 patients with hypertension and / or diabetes mellitus between June 2014 and December 2015. The glomerular filtration rate (GFR) was calculated using the Cockcroft Gault formula. A diagnosis of CKD in GFR <60 ml/min/ 1.73m at the end of follow-up was considered. To estimate the progression of CKD, the percentages of patients at each stage of kidney disease were estimated according to the Kidney Disease Improving Global Outcomes Guidelines (KDIGO), at the beginning and at the end of follow-up. To establish association between arterial hypertension and diabetes mellitus with progression of CKD, the Odds Ratio (OR) was estimated. RESULTS:  50.1% of the patients were> 65 years and 66.5% were female. The prevalence of hypertension and diabetes mellitus was 96.5% and 36.1%, respectively. At 18 months follow-up, 3.0% of patients with hypertension without diabetes mellitus progressed to CKD (Stage 3B, 4 and 5). 3.8% of patients with hypertension and diabetes mellitus progressed to CKD. The risk of progression of CKD was significantly higher in patients with hypertension with diabetes mellitus (OR: 1.30 CI 95% 1.17-1.45). CONCLUSIONS:  The presence of hypertension with diabetes mellitus was significantly associated with progression to CKD over a period of 18 months, independent of baseline GFR.