In the province of Quebec, over the past 30 years, the proportion of healthcare cost has increased significantly, regardless of all the cost containment policies that have been implemented within the system. Today, healthcare represents 48% of the government expenses. Health is a priority but it is not the only one. International organizations are searching to solve the puzzle of coping with patient access – patient centeredness - clinical relevance - affordability – breaking the silos – real world evidence as a mean to optimize patient health and control cost increase. In the province of Quebec, a pilot project is underway to address these issues: the TOWWERS program. The TOWWERS program is a dynamic, interactive, web clinical registry that shares the patient clinical summary (the DOC-P) amongst healthcare professionals and the patient. The ultimate goal of the TOWWERS program is to transform healthcare policymaking paradigm based on budgets towards clinical results, increasing accountability and collaboration of the various actors to develop relevant market access strategies and track the efficiency of treatment plans for the various actors. During this conference, we will share our ongoing experience of a major public-private health partnership of healthcare professionals, patients and their advocacy groups, payers, governments and industry.