Depression is recognised as the major cause of mental illness worldwide, affecting an estimated 22.7% of the U.S. working population (Evans-Lacko S. 2016). Depression significantly affects performance and undermines productivity with high rates of presenteeism and absenteeism (estimated annual costs of $5,524 and $390 respectively per person; total costs of ~$90-100 billion (Evans-Lacko S. 2016; Greenberg et al. 2015)). Sixty-two per cent of costs are associated with co-morbid mental disorders, such as anxiety, stress, and sleep disorders (Greenberg et al. 2015). These disorders are related to cognitive issues that depression-affected people experience in attention, memory, and executive functions, leading to complications in concentrating, solving problems, or making decisions, and are the main factors determining a presenteeism-associated lack of productivity. Solutions that specifically target depression-related, co-morbid disorders associated with presenteeism will be cost-saving. A project recently launched in a London-based, world-wide organisation, aiming to investigate, prevent, and manage potential cognitive employee health–related issues, adopts a cognitive assessment and training software, already tested in psychiatric populations (Domen A. et al. 2015; Nieman D. et al. 2015; Domen A. et al. 2016), in combination with a behavioural program targeting employees’ habits in sleep, exercise, diet, and hydration. The 15-minute online assessment used allowed employees to monitor their cognitive health from their own digital devices, while employers received an anonymised and aggregated view of cognitive health trends in their organisation. The assessment may help to raise awareness of the risk of mental illness in the workplace, enabling an evaluation of the outcomes of the combined solutions that were adopted. Assuming that a combined cognitive and behavioural program may reduce costs by 10%, U.S. employers should be able to realise a savings of around $550 per person in presenteeism costs alone.