OBJECTIVES:  This study assessed infusion times associated with GLM-IV and IFX in RA patients and factors associated with patient satisfaction for these treatments. METHODS:  An observational study in RA patients at 6 US sites assessed GLM-IV or IFX infusion time variables including: clinic visit duration - time from patient’s arrival to verbal discharge; total infusion time - time from infusion start to completion; and total infusion process time - the sum of medication preparation, patient preparation, and medication infusion times. Patient satisfaction was assessed by Treatment Satisfaction Questionnaire for Medication (TSQM-IV) and study-specific questionnaires. Descriptive statistics and comparative tests (analysis of variance for continuous and Fisher’s exact test for categorical measures) were summarized. RESULTS:  RA patients (n=150; 72 GLM-IV; 78 IFX) from 6 US sites were studied. Mean age of GLM-IV cohort was 61 years; 85% were female. The IFX cohort was older (66 years; P=0.0105), had fewer females (76%; not statistically significant—NS) and higher proportion of retirees (64% IFX vs. 40% GLM-IV). Mean weight was 83.8 kg for GLM-IV and 85.4 kg for IFX (NS). Infusions of GLM-IV and IFX averaged 3.7 and 4.9 vials, respectively. Mean clinic visit times were 65.1 (GLM-IV) and 153.1 minutes (IFX; P<0.0001). Mean medication infusion times were 32.8 (GLM-IV) and 119.5 minutes (IFX; P<0.0001). Mean infusion process times were 45.8 (GLM-IV) and 134.1 minutes (IFX; P<0.0001). Higher overall satisfaction ratings were reported by GLM-IV than IFX patients for the following: infusion time (P<0.0001), visit time (P<0.0003), and length of time the IV line was inserted (P<0.0001). CONCLUSIONS:  Shorter overall clinic, infusion process, and medication infusion times were observed for GLM-IV compared to IFX. These differences were driven primarily by shorter medication infusion time. Shorter infusion time, shorter visit time, and shorter IV insertion time were associated with higher patient satisfaction ratings.