OBJECTIVES:  This study examined the patterns and predictors of depression treatment among community-dwelling elderly individuals with comorbid dementia and depression using a nationally representative sample in United States. METHODS: A retrospective, cross-sectional study was conducted using multiple years of Medical Expenditure Panel Survey (MEPS) [2002, 2004, 2006, 2008, 2010, and 2012] data. The study sample consisted of elderly (age ≥ 65 years) individuals with dementia, depression and alive during the calendar year. Elderly individuals with dementia were identified by ICD-9-CM code of 290.XX or 294.XX or 331.XX or if they reported use of cholinesterase inhibitors or memantine. Depression was identified by ICD-9-CM code of 296.xx, or 311.xx. The dependent variable of this study was depression treatment, defined as antidepressant medication use with or without psychotherapy. Multinomial logistic regression was conducted to identify factors associated with depression treatment in the study sample. All analyses adjusted for the complex survey design of MEPS to obtain national-level estimates. RESULTS:  An overwhelming majority (nearly 88%) of the study sample (unweighted N=173) reported receipt of depression treatment. Antidepressants only and combination therapy (antidepressant with psychotherapy) was reported by 75% and 13% respectively of the study sample. Selective serotonin reuptake inhibitors (65%) and escitalopram (17.38%) were the most prescribed antidepressant class and individual agent respectively. Age, race/ethnicity, marital status, limitations of instrumental activities of daily living, perceived mental health status, and pain were significantly associated with the reporting of receipt of depression treatment. For example, Whites were approximately three (Odds Ratio=3.10, 95% CI: 1.23-7.82) and five (Odds Ratio=4.93, 95% CI: 2.30-10.5) times more likely to report use of antidepressant alone and combination therapy respectively compared with other race/ethnicities. CONCLUSIONS:  Almost 90% of individuals with comorbid dementia and depression received depression treatment and several subgroup differences existed in terms of reporting the use of depression treatment.