OBJECTIVES: The Veterans Health Administration (VHA) was an early adopter of low-dose CT (LDCT) lung cancer screening for heavy smokers (≥30 pack-year history, age 55-80) in 2013, and continues to be a critical research resource in this area. The objective of this study was to use qualitative inquiry to understand patient experiences with LDCT lung cancer screening in the VHA system. METHODS: We conducted a semi-structured telephone-based qualitative evaluation of patient experiences with LDCT screening at Portland, OR and Charleston, SC VHA sites. Participants met U.S. Preventive Services Task Force screening criteria and the sample was enriched for Lung-RADS positive results (50% of sample). Trained staff interviewed 20 participants in the summer of 2016. Interviews were recorded, transcribed, and independently evaluated by two study investigators using inductive content analysis methods to identify major themes. RESULTS: Among the 20 participants, mean age was 64 years, 95% were male, 60% were Caucasian, and 60% self-reported current smoking. Most participants were unaware of lung cancer screening before having it offered by their clinician. The majority of participants discussed a screening benefit (‘early detection’ was most common), and few discussed any screening harms. Nearly all described the experience of the screening scan as “easy”, “quick”, and/or “painless”. Most participants with positive results expressed desire for more information about screening and results, whereas few with negative results did. Participant quotes supporting these themes will be presented. CONCLUSIONS: Among participants who recently received LDCT screening in the VHA system, screening was frequently introduced by clinicians, screening benefits were noted more often than harms, the screening exam was often described as ‘easy’, and patients with positive results wanted more information about screening. Our findings provide insights to help VHA and other stakeholders understand patient perspectives on LDCT screening, and can be used to inform efforts to improve screening processes.