OBJECTIVES:  To explore the patients and basic understanding of medicines in Saudi Arabia METHODS:  It is a 4-months cross-sectional survey of patient and basic knowledge of medicines. The questionnaire consisted of two-part demographic information, and second part forty-nine questions divided into four domains. It included basic information about medication, patient information about the drug related problem, patient information about drug-related cost, and patient perception of medications. MedlinePlus and DailyMed health information used. The 5-points Likert response scale system used. The survey distributed through social media and at 500-bed pediatrics and maternity hospital in Asir region, at ambulatory care pharmacy. The survey made an electronic format, and it analyzed domain one through survey monkey system RESULTS:  The total responders were (614) Saudi patients. The gender distribution 523 (86.7%) was female, and 91(13.3%) was male. The majority of them in age (18-44) 78.3% and located at Asir region 325 (115%) and Riyadh region 163 (46.9%). The most type of medications used was anti-diabetic and anti-hypertension medicines, Skin medications, and drugs for Respiratory diseases. The responders showed poor knowledge either they do not know or weak information about the generic name of Medicines 300 (54.8%), the trade name 146 (46.8%), drug strength 182 (34.2%). The responder showed adequate knowledge about medications with complete information about drug indication 333 (56.8%), how to use medications 419 (71.6%), the administration time 419 (72%), the potential to adhere medication 325 (55.7%), and the time to stop drugs 293 (50%). The majority of responders used health care providers 346 (57%), drug bulletin 341 (56.2%), and Internet 221 (36.4%) as sources of drug information CONCLUSIONS: The finding showed indigent essential drug information knowledge. Targeting of public awareness of basic information about their medications and patient counseling system will prevent drug misadventures and drug-related morbidity and mortality in Saudi Arabia.