OBJECTIVES: To examined the national trends and predictors associated with antipsychotic use among individuals with schizophrenia. METHODS: A retrospective cross-sectional study were conducted using 2008–2013 Medical Expenditure Panel Survey (MEPS) data. Descriptive and Chi-square tests were used to describe patterns of antipsychotic use. Multivariate logistic regression analyses were conducted to explore the relationship between the different variables in the study with antipsychotic use. RESULTS: Overall, antipsychotic-medication users decreased from 582,581 in 2008 to 478,553 in 2013, a 17% decrease. The multivariate analyses revealed that no antipsychotic use was associated with patients who were older than 59 [OR=0.28, 95% CI= 0.08, 0.94], female [OR=0.44, 95% CI= 0.26, 0.74], non-white [OR=0.34, 95% CI= 0.19, 0.62], previously or never married [OR=7.88, 95% CI= 3.13, 19.84], or who had prescription coverage by Medicare, Medicaid or other [OR=3.38, 95% CI= 1.38, 8.29], [OR=3.89, 95% CI= 1.74, 8.72], or [OR=7.29, 95% CI= 2.25, 23.66], respectively. Respondents who perceived themselves as having good general health were negatively associated with not receiving antipsychotic medication [OR=0.42, 95% CI= 0.23, 0.76]. CONCLUSIONS: During the study period, antipsychotic medication use declined for patients with schizophrenia. This finding suggests targeting subgroups for specific improvement strategies to protect high-risk patients with schizophrenia.